Uterotropic activity of DDT in rats and mink and its influence on reproduction in the rat.

Uterotropic Activity of DDT in Rats and Mink and Its Influence on Reproduction in the Rat. DUBY, R . T., TRAVIS, H. F., and TERRILL, C. E. (1971). Toxicol. Appl. Pharmacal. 18, 348-355. The injection of o,p'-DDT increased uterine weights in intact immature rats, and in intact and castrate immature minlc The p,p' -isomer had only slight activity while the uterotropic activity of technical DDT was dependent upon the level of the o,p'isomer it contained. Chronic ingestion of these compounds by rats at levels of 1 to 15 ppm in the diet did not influence fertility or fecundity in 2 successive generations. The time of vaginal opening, growth rate, and litter size was not influenced. The injection of 90 or 900 f-Lg of p,p' -DDT or o,p' -DDT on days 1, 2, and 3 of pregnancy did not influence tije number of embryos surviving to day 10 of pregnancy in the rat. However, following castration of adult female rats raised on DDT -containing diets, uterine involution was accelerated in animals receiving 15 ppm technical DDT.